Expert Review of Gastroenterology & Hepatology

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全世界胃肠道疾病的巨大健康和经济负担使得人们必须高度重视新疗法的病因、流行病学、预防、诊断、治疗和发展。到上个世纪末，我们已经看到了巨大的进步，无论是在可视化疾病的技术上，还是在胃溃疡等领域的治疗上，H2拮抗剂的出现，然后质子泵抑制剂的出现，都清楚地说明了医学的进步如何能使患者受益。然而，专家们面临着来自各种病因的疾病的持续挑战。在相关的肝病领域，仅在美国，肝病和肝硬化是25-64岁成年人的第七大死因。具体来说，乙型肝炎的传染性是艾滋病病毒的100倍，目前全世界有5%的人口受到感染。随着科学界和临床界用新技术、新的治疗和诊断方式以及在分子水平上对疾病的新理解来应对这些挑战，科学文献正在爆炸性地激增。胃肠病和肝病专家评论（ISSN1747-4124）提供了最新研究和临床进展的全面报道。该杂志关注我们对影响胃肠道和肝脏疾病的病理、生化和生理学理解的最新进展，以及预防、诊断和干预策略的最新发展。文章涵盖以下关键领域：?对消化系统及其相关器官疾病的病理、生化和生理学理解的最新进展?研究策略的发展，如放射学、内窥镜检查、胆胰造影、结肠镜检查和肝活检?分子诊断和生物标记研究进展?药理学方法和新兴治疗学的最新进展?药物安全性?疾病特异性综述，包括消化癌、肝炎感染、肝硬化、炎症性肠病、功能性胃肠道疾病、胆道和胆囊疾病的报道。?针对诊断和问题，如吸收、营养和生长，对儿童消化系统疾病进行最佳管理。?心理社会方面?药理学和结果研究，辅以成本效益分析专家评审的形式是独特的，因为它培养了一种前瞻性的思维方式。每一次审查都提供了对关键领域当前理解的完整概述，并通过以下关键部分加以补充：专家意见-对本文中所述数据的个人观点，对未来可能重要的发展的讨论，以及随着进一步研究产生更详细的结果，研究的途径可能变得令人兴奋。文章重点——作者最关键点的执行摘要所有评审都要接受同行评审，至少要进行三次独立评审。胃肠病和肝病专家评审为本专业所有专业人员提供了一个系统、权威的分析和辩论的平台。

The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology. In the related field of hepatology, liver disease and cirrhosis are the seventh leading cause of death among adults between 25–64 years of age in the USA alone. Specifically, Hepatitis B is 100 times more infectious than the AIDS virus and currently 5% of the population, worldwide, is infected. As the scientific and clinical communities address these challenges with new technologies, new therapeutic and diagnostic modalities and new understanding of disease at the molecular level, the scientific literature is proliferating explosively. Expert Review of Gastroenterology & Hepatology (ISSN 1747-4124) provides comprehensive coverage of state-of-the-art research and clinical advancements in the field as they occur. The journal focuses on the latest advances in our pathological, biochemical and physiological understanding of the diseases affecting the gastrointestinal tract and liver, in addition to up-to-the-minute developments in strategies for prevention, diagnosis and intervention. Article coverage includes the following key areas: ? Latest advances in pathological, biochemical and physiological understanding of the diseases of the digestive system and its associated organs ? Developments in investigative strategies; such as radiology, endoscopy, cholangiopancreatography, colonoscopy and liver biopsy ? Advances in molecular diagnosis and biomarker research ? Recent developments in pharmacological approaches and emerging therapeutics ? Drug safety ? Disease-specific reviews, including coverage of digestive cancers, hepatitis infections, liver cirrhosis, inflammatory bowel disease, functional gastrointestinal disorder, and biliary and gall bladder disease ? Optimal management of pediatric digestive diseases, with regard to diagnosis and issues, such as absorption, nutrition and growth ? Psychosocial aspects ? Pharmacoeconomics and outcomes research, supplemented by cost–benefit analysis The Expert Review format is unique in that it fosters a forward-thinking approach. Each review provides a complete overview of current understanding in a key area, which is augmented by the following key sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points All reviews are subject to peer review, with a minimum of three independent evaluations. Expert Review of Gastroenterology & Hepatology provides a forum for systematic, authoritative analysis and debate for all professionals within this specialty.