TOXICOLOGY MECHANISMS AND METHODS

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《毒理学机制与方法》是一份同行评审的期刊，每季出版一期，其目标是双重的。首先，该杂志包含了关于外来化学物质引起毒性组织损伤机制的原始研究。感兴趣的化学物质包括工业化合物、环境污染物、危险废物、药物、杀虫剂和化学战剂。该杂志的范围从分子和细胞的作用机制，到考虑建立监管政策的机制证据。其次，该杂志涉及开发、验证和应用新的和现有的实验室方法、技术和设备。讨论了多种研究方法，包括:用标准种和替代种进行体内研究;体外研究和替代方法;分子、生化和细胞技术;药物动力学和药效学;数学建模和计算机程序;法医分析;风险评估;数据收集和分析。毒理学机制和方法为来自工业、政府和学术界的毒理学家、药理学家和生物化学家等众多专业人士提供了关于有毒物质测定、评价和检测及其影响的最关键问题的全面报道。

Published quarterly, Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: in vivo studies with standard and alternative species; in vitro studies and alternative methodologies; molecular, biochemical, and cellular techniques; pharmacokinetics and pharmacodynamics; mathematical modeling and computer programs; forensic analyses; risk assessment; data collection and analysis. Toxicology Mechanisms and Methods provides comprehensive coverage of the most critical issues in the determination, evaluation and testing of toxic substances and their effects for a wide variety of professionals, including toxicologists, pharmacologists, and biochemists from industry, government and academia.