CANCER BIOLOGY & THERAPY

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影响因子:3.294五年影响因子:3.380Thomson Reuters, Journal Citation Reports?for 2016将癌症生物学和治疗在217个肿瘤学领域中排名92位。目标和范围:癌症是第二大致死原因，是一个由100多种疾病组成的异质性群体。癌症的特征是细胞和基质细胞的无序和不受控制的增殖，伴随着细胞死亡的减少，在营养和生长因子缺乏、缺氧和细胞间接触减少的压力下，细胞能够存活。在分子水平上，癌症是一种遗传疾病，是由于体细胞随时间积累突变而发展起来的。表型包括基因组不稳定性和允许加速遗传变化的染色体非整倍体。任何细胞的恶性转化和肿瘤进展都需要永生、检查点失控、生长失调和生存。关于伴随肿瘤发展和进展的大量细胞和分子遗传变化以及宿主与肿瘤的相互作用已经有了大量的了解。这是分子肿瘤学领域的目标，利用这一知识来了解癌症的发病机制和药物作用，以及开发更有效的癌症诊断和治疗策略。这包括预防策略以及治疗转移的方法。随着人类基因组序列和基因组和蛋白质组方法的可用性，大量的工具和资源正在产生更多的信息。挑战在于从这些信息中找出生物学意义，建立适当的模型和假设，并为临床医生和患者的利益翻译信息。《癌症生物学与治疗》旨在发表关于癌症分子基础的原创研究，包括与诊断或治疗相关的翻译文章。我们将包括及时的评论涵盖广泛的期刊范围。该杂志还将发表评论文章和感兴趣的会议报告。其目标是通过使用传统和电子格式及时发表重要成果，促进交流和迅速交换信息。该杂志和杰出的编辑委员会将努力保持在所有活动的卓越的最高标准，以产生宝贵的资源。

Impact Factor: 3.294Five-Year Impact Factor: 3.380? 2017 Thomson Reuters, Journal Citation Reports ? for 2016 ranks Cancer Biology & Therapy 92 out of 217 in Oncology.Aims & Scope: Cancer, the second leading cause of death, is a heterogenous group of over 100 diseases. Cancer is characterized by disordered and deregulated cellular and stromal proliferation accompanied by reduced cell death with the ability to survive under stresses of nutrient and growth factor deprivation, hypoxia, and loss of cell-to-cell contacts. At the molecular level, cancer is a genetic disease that develops due to the accumulation of mutations over time in somatic cells. The phenotype includes genomic instability and chromosomal aneuploidy that allows for acceleration of genetic change. Malignant transformation and tumor progression of any cell requires immortalization, loss of checkpoint control, deregulation of growth, and survival. A tremendous amount has been learned about the numerous cellular and molecular genetic changes and the host-tumor interactions that accompany tumor development and progression. It is the goal of the field of Molecular Oncology to use this knowledge to understand cancer pathogenesis and drug action, as well as to develop more effective diagnostic and therapeutic strategies for cancer. This includes preventative strategies as well as approaches to treat metastases. With the availability of the human genome sequence and genomic and proteomic approaches, a wealth of tools and resources are generating even more information. The challenge will be to make biological sense out of the information, to develop appropriate models and hypotheses and to translate information for the clinicians and the benefit of their patients. Cancer Biology & Therapy aims to publish original research on the molecular basis of cancer, including articles with translational relevance to diagnosis or therapy. We will include timely reviews covering the broad scope of the journal. The journal will also publish op-ed pieces and meeting reports of interest. The goal is to foster communication and rapid exchange of information through timely publication of important results using traditional as well as electronic formats. The journal and the outstanding Editorial Board will strive to maintain the highest standards for excellence in all activities to generate a valuable resource.