JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

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PMC链接：http://www.ncbi.nlm.nih.gov/nlmcatalog?term=1570-0232%5BISSN%5D

《色谱学杂志B》发表了与生物学和生物医学研究有关的分离科学发展的论文，包括基本进展和应用。可以考虑的分析技术包括色谱、电泳和相关方法的各个方面、亲和力和免疫亲和力为基础的方法、连字符技术和其他多维技术以及微分析方法。该杂志还考虑了报告样品制备、包括质谱分析在内的检测技术以及数据处理和分析进展的文章。与分离纯化生物系统成分的制备分离相关的进展可能会公布，包括色谱和电泳方法、亲和分离、场流分离和其他制备方法。当分析科学包含一个重要的新颖性元素时，将考虑生物系统和样品分析的应用，例如化合物分离的新方法、分析技术的新组合或显著改进的分析性能。需要考虑的领域包括：包括蛋白质、单克隆抗体、肽及其翻译后修饰以及核酸和聚糖在内的生物聚合物的定性和定量分析；利用蛋白质组学、基因组学、代谢组学、脂质组学和其他“组学”方法对生物系统进行比较分析；临床分析、代谢、治疗药物监测、毒理学分析、兴奋剂分析、兽医应用、生物系统环境污染物分析；体液、组织、细胞、生物基质和系统的筛选和分析、内源性化合物、生物标志物；新生物活性化合物的鉴定。使用已出版的或商业化的分析性或准备性协议而很少或没有修改的应用，或应用结果而不是分析方法构成手稿新颖性的主要因素的应用，应定向到更专业的期刊。在性能显著改善的情况下，可以考虑对先前发布的方法进行修改，以便进行简短的沟通。关于药物开发早期化合物分析方法的报告往往缺乏普遍兴趣，除非作者能够证明所涉及方法的更广泛意义，否则不会发表。散装药物、天然产品或小分子药物制剂的质量控制分析不在范围内。

The Journal of Chromatography B publishes papers on developments in separation science relevant to biology and biomedical research including both fundamental advances and applications. Analytical techniques which may be considered include the various facets of chromatography, electrophoresis and related methods, affinity and immunoaffinity-based methodologies, hyphenated and other multi-dimensional techniques, and microanalytical approaches. The journal also considers articles reporting developments in sample preparation, detection techniques including mass spectrometry, and data handling and analysis.Developments related to preparative separations for the isolation and purification of components of biological systems may be published, including chromatographic and electrophoretic methods, affinity separations, field flow fractionation and other preparative approaches.Applications to the analysis of biological systems and samples will be considered when the analytical science contains a significant element of novelty, e.g. a new approach to the separation of a compound, novel combination of analytical techniques, or significantly improved analytical performance. Areas to be considered include:The qualitative and quantitative analysis of biopolymers including proteins, monoclonal antibodies, peptides and their post-translational modifications as well as nucleic acids and glycansThe comparative analysis of biological systems using proteomics, genomics, metabolomics, lipidomics and other "omics" approachesClinical analysis, metabolism, therapeutic drug monitoring, toxicological analysis, doping analysis, veterinary applications, analysis of environmental contaminants in biological systemsThe screening and profiling of body fluids, tissues, cells, biological matrices and systems, analysis of endogenous compounds, biomarkersIdentification of new bioactive compoundsApplications which utilize published or commercial analytical or preparative protocols with little or no modification or where the results of the application rather than the analytical methodology comprise the major element of novelty of the manuscript should be directed to more specialized journals. Modifications to a previously published method may be considered for a short communication in cases where the improvement in performance is significant. Reports of analytical methods for compounds in early pharmaceutical development often lack general interest and will not be published unless the authors can demonstrate the broader significance of the methodology involved. Quality control analyses of bulk drugs, natural products or pharmaceutical formulations of small molecules are not within scope.