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《蛋白质科学》是蛋白质学会的旗舰期刊，为发表有关蛋白质分子所有科学方面的原始报告提供了一个国际论坛。该杂志发表了来自世界各地的顶尖科学家的论文，报告了在最广义上对蛋白质的理解方面的进展。蛋白质科学的目标是通过跨越既定的学科界限，聚焦于“以蛋白质为中心”的科学，从而统一这一领域。该杂志包括蛋白质的结构、功能和生化意义，它们在分子和细胞生物学、遗传学和进化中的作用，以及它们的调控和作用机制。特别感兴趣的题目包括但不限于:■蛋白质结构和用化学、生物物理和重组方法确定蛋白质结构的策略■肽■蛋白质域■蛋白质折叠和分子动力学新型隔离程序■酶的作用和调节■蛋白质与核酸、脂类、配体和其他蛋白质的相互作用■受体介导的信号转导等跨膜现象■蛋白质在复制、超分子组装、免疫反应、发育等生物学过程中的功能■蛋白质的转运、合成和分选■蛋白质的识别、定位和信号转导除了上述的研究技术，该杂志还将发表以下以蛋白质为中心的研究结果:■测序、修饰和质谱分析■cDNA、诱变和克隆■计算分析■分离与表征■热力学和流体动力学■动力学■平衡现象蛋白质科学出版完整的原始研究论文，以及评论和书评。回忆(仅凭邀请)是一种历史回顾，旨在概述蛋白质科学中某个特定主题是如何发展起来的。有一个特别部分，供记录，其中载有关于该领域最近发展情况的简要参考报告(即;本节可能突出显示一个新的蛋白质序列或报告一个新的蛋白质结构和/或功能)。审查(仅邀请)的目的是使一般读者熟悉迅速发展的当前感兴趣的主题的现状和未来趋势。

Protein Science, the flagship journal of The Protein Society, serves an international forum for publishing original reports on all scientific aspects of protein molecules. The Journal publishes papers by leading scientists from all over the world that report on advances in the understanding of proteins in the broadest sense. Protein Science aims to unify this field by cutting across established disciplinary lines and focusing on “protein-centered” science.The Journal encompasses the structure, function, and biochemical significance of proteins, their role in molecular and cell biology, genetics, and evolution, and their regulation and mechanisms of action. Topics of particular interest include, but are not limited to: ■ Structure of proteins and strategies of determining protein structure by chemical, biophysical, and recombinant methods ■ Peptides ■ Protein domains ■ Protein folding and molecular dynamics ■ Novel isolation procedures ■ Enzyme action and regulation ■ Interactions of proteins with nucleic acids, lipids, ligands, and other proteins ■ Receptor-mediated signal transduction and other trans-membrane phenomena ■ The functions of proteins in replication, supramolecular assembly, immune reactions, development, and other biological processes ■ Protein trafficking, synthesis and sorting ■ Recognition, localization and signaling of proteinsIn addition to the investigative techniques aforementioned, the Journal will publish results of protein-centered work involving: ■ Sequencing, modification, and mass spectrometry ■ cDNA, mutagenesis and cloning ■ Computational analysis ■ Isolation and characterization ■ Thermodynamics and hydrodynamics ■ Kinetics ■ Equilibrium phenomenaProtein Science publishes full-length original research papers as well as reviews and book reviews. Recollections (by invitation only) are historical reviews that are intended to give an overview of how a particular topic in the science of proteins has developed. A special section, For the Record, features brief refereed reports of recent developments in the field (i.e.; this section may highlight a new protein sequence or report a new protein structure and/or function). Reviews (by invitation only) are intended to familiarize the general reader with the current status and future trends of rapidly evolving topics of current interest.